Comparison of human epidermal growth factor receptor 2 and cancer stem cell markers like CD44 and CD133 expressions with clinicopathological parameters in gastric cancer

Objectives: Gastric carcinoma (GC) is the fourth most common cause of cancer-related tumor deaths worldwide. The prognostic significance CD44, CD133 and human epidermal growth factor receptor 2 (HER2) expression in GC remains controversial. Therefore, we aimed to investigate relationship HER2 with clinicopathological features metastatic non-metastatic patients. Methods: A total 139 patients (68 metastasis, 71 without metastasis) diagnosed were retrospectively analyzed. CD44 determined by immunohistochemical method all cases. In addition, overexpression was evaluated GC. Results: positivity rate 90.6% (n = 126) when cases considered, that for 84.9% 118). There no difference (intensity or density) rates between scores (p > 0.05). detected 49 (70.1%) method. No correlation found score age, size depth, analyzes performed scores, only a borderline significant (r:0.175; p 0.047) Conclusions: We demonstrated associations CD44/CD133 histological grade patients, intestinal type (Lauren) results this study need be confirmed multicenter studies including large case series.